Monday, March 02, 2009

Permenant protection againts the flu?

Researchers have discovered antibodies that disable multiple varieties of the flu virus by targeting the virus's protein that covers its surface allowing it to attach to it's receptor on it's surface known as hemagglutinin. The hemagglutinin then performs contortions that enable it to merge the virus's membrane with the cell's membrane.

At the moment vaccines mainly send antibodies that target the hemagglutinin's head, but that part of the protein changes rapidly, undermining these immune defenses. But now they've discovered an unchanging part of hemagglutinin and even identified 10 antibodies that recognized different versions of this part of the hemagglutinin, also known as H5. So far these antibodies have been able to block not only H5 but also eight other types of flu virus in solution. When given to infected mice 3 days after the infection, most of the rodents survived, suggesting the antibodies are therapeutic and preventive.

Another discovery showed that instead of attaching to the hemagglutinin's head, the antibody attaches to three pockets on the stem of the virus and that the amino acid sequence found in this region is the same in other viral strains. That means that an antibody that recognizes this region alone could protect against a variety of flu strains possibly even the avian flu.


-Lysander Ning

5 Comments:

At 11:03 PM, March 04, 2009, Anonymous Anonymous said...

That sounds like a flu shot I would be interested in getting. I think half the campus has gotten the flu in the past couple weeks, me included. Were the different strains of flu you were talking about morphs of the same type, like the yearly flu most people get, or different types like the stomach flu vs avian flu.
-Nick Cline

 
At 11:06 AM, March 05, 2009, Anonymous Anonymous said...

This discovery is very interesting. I would like to know if the discoverers have found any negative effects that may stem from this protection or it would be nice to know possible side effects...? The flu is very common and this protection sounds great. Do you think the flu virus, like many other viruses, will evolve to reject this protection?

 
At 11:06 AM, March 05, 2009, Anonymous Anonymous said...

by Shonneau L. (3)

 
At 12:01 PM, March 05, 2009, Anonymous Anonymous said...

I'm glad they are finding "cures" or remedies for the flu. Not many people die from it, but still today people do. I really hope they can help fight avian flu also.

-Katie Cyr

 
At 9:58 AM, March 09, 2009, Anonymous Anonymous said...

Pretty cool how they've found these antibodies that can target different types of viruses. I wonder for how many different types of viruses have they tested this and if it has been tested on humans yet?

-Julio Rodriguez

 

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